Dave Kokel, PhD

ASST PROF IN RES-HCOMP
+1 415 502-7609
Publications: 

A non-hallucinogenic psychedelic analogue with therapeutic potential.

Nature

Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies.

Journal of medicinal chemistry

Dunlap LE, Azinfar A, Ly C, Cameron LP, Viswanathan J, Tombari RJ, Myers-Turnbull D, Taylor JC, Grodzki AC, Lein PJ, Kokel D, Olson DE

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.

Nature communications

McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.

Nature chemical biology

Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D

s1 receptor ligands control a switch between passive and active threat responses.

Nature chemical biology

Rennekamp AJ, Huang XP, Wang Y, Patel S, Lorello PJ, Cade L, Gonzales AP, Yeh JR, Caldarone BJ, Roth BL, Kokel D, Peterson RT

Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.

ACS chemical biology

McCarroll MN, Gendelev L, Keiser MJ, Kokel D

Identification of nonvisual photomotor response cells in the vertebrate hindbrain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kokel D, Dunn TW, Ahrens MB, Alshut R, Cheung CY, Saint-Amant L, Bruni G, Mateus R, van Ham TJ, Shiraki T, Fukada Y, Kojima D, Yeh JR, Mikut R, von Lintig J, Engert F, Peterson RT

Photochemical activation of TRPA1 channels in neurons and animals.

Nature chemical biology

Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT

An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.

Journal of biomolecular screening

Jin S, Sarkar KS, Jin YN, Liu Y, Kokel D, Van Ham TJ, Roberts LD, Gerszten RE, Macrae CA, Peterson RT

Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology.

Trends in biotechnology

Kokel D, Rennekamp AJ, Shah AH, Liebel U, Peterson RT

Chemical informatics and target identification in a zebrafish phenotypic screen.

Nature chemical biology

Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL, Roth BL, Peterson RT, Shoichet BK

cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish.

Molecular reproduction and development

Groeneweg JW, White YA, Kokel D, Peterson RT, Zukerberg LR, Berin I, Rueda BR, Wood AW

Live imaging of apoptotic cells in zebrafish.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

van Ham TJ, Mapes J, Kokel D, Peterson RT

Rapid behavior-based identification of neuroactive small molecules in the zebrafish.

Nature chemical biology

Kokel D, Bryan J, Laggner C, White R, Cheung CY, Mateus R, Healey D, Kim S, Werdich AA, Haggarty SJ, Macrae CA, Shoichet B, Peterson RT

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation.

Science (New York, N.Y.)

Rihel J, Prober DA, Arvanites A, Lam K, Zimmerman S, Jang S, Haggarty SJ, Kokel D, Rubin LL, Peterson RT, Schier AF

Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish.

Briefings in functional genomics & proteomics

Kokel D, Peterson RT

A class of benzenoid chemicals suppresses apoptosis in C. elegans.

Chembiochem : a European journal of chemical biology

Kokel D, Xue D

Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.

Nature

Yan N, Chai J, Lee ES, Gu L, Liu Q, He J, Wu JW, Kokel D, Li H, Hao Q, Xue D, Shi Y

Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.

Molecular cell

Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, Shi Y