David Kokel, PhD

A non-hallucinogenic psychedelic analogue with therapeutic potential.

Nature

Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies.

Journal of medicinal chemistry

Dunlap LE, Azinfar A, Ly C, Cameron LP, Viswanathan J, Tombari RJ, Myers-Turnbull D, Taylor JC, Grodzki AC, Lein PJ, Kokel D, Olson DE

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.

Nature communications

McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D

Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.

Molecular cell

Breckenridge DG, Kang BH, Kokel D, Mitani S, Staehelin LA, Xue D

Publications

A non-hallucinogenic psychedelic analogue with therapeutic potential.

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies.

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.

s1 receptor ligands control a switch between passive and active threat responses.

Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.

Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish.

Identification of nonvisual photomotor response cells in the vertebrate hindbrain.

Photochemical activation of TRPA1 channels in neurons and animals.

An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.

Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology.

Apoptotic cells are cleared by directional migration and elmo1- dependent macrophage engulfment.

Chemical informatics and target identification in a zebrafish phenotypic screen.

Using the zebrafish photomotor response for psychotropic drug screening.

cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish.

Live imaging of apoptotic cells in zebrafish.

Rapid behavior-based identification of neuroactive small molecules in the zebrafish.

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation.

Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish.

Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.

A class of benzenoid chemicals suppresses apoptosis in C. elegans.

The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans.

Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.

Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.