
Professor in Residence
Memory and Aging Center
Publications
Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases.
Alzheimer's & dementia : the journal of the Alzheimer's Association
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau.
Nature communications
The relationship between caloric intake and clinical outcomes in critically ill patients: A retrospective study.
Clinical nutrition ESPEN
mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes.
Journal of neuroinflammation
Second international symposium on the chaperone code, 2023.
Cell stress & chaperones
The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness.
Human molecular genetics
Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Molecular neurodegeneration
Mutations in a-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Molecular neurodegeneration
Tuberous sclerosis complex is associated with a novel human tauopathy.
Acta neuropathologica
Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling.
Stem cell reviews and reports
Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model.
ACS chemical neuroscience
TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.
Science advances
Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
Molecular neurodegeneration
Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation.
Frontiers in neurology
Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics.
Frontiers in neuroscience
Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia.
JAMA neurology
Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons.
Scientific reports
Protons in small spaces: Discrete simulations of vesicle acidification.
PLoS computational biology
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
Stem cell reports
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.
NPJ aging and mechanisms of disease
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.
Human molecular genetics
Progranulin Stimulates the in vitro Maturation of pro-Cathepsin D at Acidic pH.
Journal of molecular biology
Tauopathy-Associated PERK Alleles are Functional Hypomorphs that Increase Neuronal Vulnerability to ER Stress.
Human molecular genetics
The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response.
Methods in molecular biology (Clifton, N.J.)
Clinicopathological correlations in behavioural variant frontotemporal dementia.
Brain : a journal of neurology
Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia.
Acta neuropathologica
Progranulin, lysosomal regulation and neurodegenerative disease.
Nature reviews. Neuroscience
MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes.
Alzheimer's & dementia (Amsterdam, Netherlands)
The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience
The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier).
Alzheimer's & dementia : the journal of the Alzheimer's Association
Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development.
Alzheimer's & dementia : the journal of the Alzheimer's Association
A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
Proceedings of the National Academy of Sciences of the United States of America
Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy.
Alzheimer disease and associated disorders
Chemokine receptors, neural progenitor cells, and the AIDS dementia complex.
The Journal of infectious diseases
Functional comparison of the role of dynamin 2 splice variants on GLUT-4 endocytosis in 3T3L1 adipocytes.
American journal of physiology. Endocrinology and metabolism
Dynamin is required for recombinant adeno-associated virus type 2 infection.
Journal of virology
Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4.
The Journal of biological chemistry
The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism.
The Journal of biological chemistry
Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling.
The Journal of biological chemistry
Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways.
Molecular and cellular biology
The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway.
The Journal of biological chemistry
Insulin Stimulates the Phosphorylation of the 66- and 52-Kilodalton Shc Isoforms by Distinct Pathways*.
Endocrinology
Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways.
Endocrinology
Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation.
The Journal of biological chemistry
Evidence for myosin motors on organelles in squid axoplasm.
Proceedings of the National Academy of Sciences of the United States of America